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What is a Tryptamine and Why are they so Trippy?

When psychedelic nerds talk about tryptamines, this is what they mean. LSD and ibogaine are mostly here for contrast since they are much less tryptamines than the rest as you can see, but notice it isn't just psychedelics on here, our old friends serotonin and melatonin are actually the most well known and understood tryptamines, only a few endogenous (made in the body) enzymatic steps away from DMT! Also shown here are tryptophan and tryptamine. Tryptophan is found in basically every meal you eat, there's so many foods with it (not just turkey) and you've probably seen it in supplement bottles. Well it's shown here because with a lil decarboxylation it turns into trypamine, which is the core structure of all of what you see here. Add another methyl group to that and you have DMT. 5-MeO-DMT and bufotenin are very potent psychedelic compounds found in nature and probably our brains as well. I'll be talking a lot more about 5-MeO-DMT going forward, btw. The therapeutic potential of that drug is mind blowing. And of course we have our friends psilocybin and it's metabolically simpler partner psilocin, also just a few enzymatic steps away from DMT and tryptamine (although I don't think that happens in the body, just mushrooms). I like to imagine the mushroom gods got a hold of DMT and were like, "that's cute, I bet I could make it better," and created a more stable, longer lasting and easier to integrate experience. There's tons more trypamines, but as you can see they are pretty important and they are TRYPPY!! Even serotonin and melatonin play a huge role in shaping our states of consciousness. If you can't tell by now, I'm doing my darndest to destigmatize and integrate these sometimes scary molecules. My whole life, I've experienced things go from scary to "OMG why didn't I find out about this sooner!?" and this is one of those things. DMT and it's friends are a normal part of nature and consciousness. They aren't evil, they aren't illusions, they are real. #psychedelicintegration#psychedelicmeme#spiritualmemes#psychedelics#spiritualawakening#magicmushrooms#dmtspiritmolecule#psilocybinmushrooms #psychedelicmemes


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